Synthesis of the key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the immunomodulatory agent FTY720 (fingolimod).

نویسندگان

  • Norimasa Matsumoto
  • Ryoji Hirose
  • Shigeo Sasaki
  • Tetsuro Fujita
چکیده

The key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate (13), for the immunomodulatory agent FTY720 (2: fingolimod) was synthesized via Michael addition of diethyl(acetylamino)malonate (6) to 4-octanoylstyrene (12).

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catena-Poly[3,3′-diethyl-1,1′-(propane-1,3-di­yl)di(1H-imidazol-3-ium) [silver(I)-di-μ-iodido-silver(I)-di-μ-iodido]]

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عنوان ژورنال:
  • Chemical & pharmaceutical bulletin

دوره 56 4  شماره 

صفحات  -

تاریخ انتشار 2008